Frontier vs. weaker models

Same query, same tools, different models — judged on the expert rubric. This is what an environment is for: it discriminates model quality. Pick a workflow.

Adverse-Event Coding & Causality

Claude Opus 4.8: 5.0 GPT (frontier): 4.4 Claude Haiku 4.5: 3.8 GPT-4o mini: 2.8

BD Asset Due Diligence & Valuation (rNPV)

Claude Opus 4.8: 3.4 Claude Haiku 4.5: 3.0 GPT (frontier): 2.8 GPT-4o mini: 2.2

Competitive Trial-Landscape Analysis

Claude Opus 4.8: 4.0 GPT (frontier): 3.2 Claude Haiku 4.5: 3.0 GPT-4o mini: 1.0

Eligibility-Criteria Authoring

Claude Opus 4.8: 4.8 GPT (frontier): 4.8 Claude Haiku 4.5: 4.4 GPT-4o mini: 4.0

First-in-Human Starting-Dose Selection

Claude Haiku 4.5: 5.0 Claude Opus 4.8: 5.0 GPT (frontier): 5.0 GPT-4o mini: 3.4

Patent / Freedom-to-Operate Analysis

Claude Opus 4.8: 4.6 Claude Haiku 4.5: 3.8 GPT-4o mini: 2.0 GPT (frontier): 1.4

Epidemiology-Based Market Sizing

Claude Opus 4.8: 3.8 GPT (frontier): 3.6 Claude Haiku 4.5: 2.6 GPT-4o mini: 2.4

FDA Regulatory Strategy & Designation Planning

Claude Opus 4.8: 4.8 GPT-4o mini: 3.8 Claude Haiku 4.5: 3.6 GPT (frontier): 3.2

Systematic Review & Meta-Analysis

Claude Opus 4.8: 3.6 GPT (frontier): 3.2 Claude Haiku 4.5: 3.0 GPT-4o mini: 1.2

Target Validation & Tractability

Claude Opus 4.8: 4.6 GPT-4o mini: 4.2 GPT (frontier): 4.2 Claude Haiku 4.5: 4.0